How does typhoid hijack human cell biology?
The bacterial pathogen Salmonella Typhi causes typhoid fever, which is a global health problem. Daniel Humphreys and his team at the Department of Biomedical Science, University of Sheffield, investigate how Salmonella attacks the DNA in human cells to rewire our biology and evade detection by our immune system.
Daniel Humphreys is a UKRI Future Leaders Research Fellow at the Department of Biomedial Science, University of Sheffield. His research group studies how Salmonella Typhi hijacks human cell biology to cause typhoid fever. His team is particularly interested in how Salmonella Typhi evades and manipulates human cell defences to infection. Unravelling the disease mechanisms aims to help discover new therapeutic interventions and combat the global threat posed by typhoid.