What is Hi-Co? – A technology for 3D genome structure analysis at the highest resolution
Whole genome sequencing – determining the full sequence of DNA in an organism – has taught scientists a huge amount about biology. However, what is often lacking is a picture of how those pieces of DNA are arranged. Hi-Co – a new technology for analysing nucleosome positions and orientations across the genome – could change this, by bringing together next-generation sequencing experiments and super-computer simulations.
Taniguchi group at iCeMS in Kyoto University: Biological functions such as cellular differentiation are often regulated by vast numbers of molecules. Elucidating the general
principles behind the organization of these complex molecular environments is a critical challenge. Our laboratory addresses this challenge by developing new technologies for the large scale characterization and manipulation of intracellular molecular activities. By integrating knowledge from multiple academic fields, including biology, chemistry, physics, medicine, and
informatics, we aim to understand, predict, and control intracellular molecular interactions.