What is Hi-Co? – A technology for 3D genome structure analysis at the highest resolution

Project specs




Christopher Monahan



Funding agency

This work was supported by PRESTO; Japan Science andTechnology Agency (JPMJPR15F7); grants-in-aid for ScientificResearch (A) (20H00460), Challenging Exploratory Research(26650055), Challenging Pioneering Research (19H05545 and20K20458) and Scientific Research on InnovativeAreas(23115005); Japan Society for the Promotion of Science; andgrants from the RIKEN Epigenome Manipulation Project, RIKENIncentive Research Projects, Astellas Foundation for Research onMetabolic Disorders, Suntory Rising Stars EncouragementProgram in Life Sciences (SunRiSE), the Takeda ScienceFoundation, and the Mochida Memorial Foundation for Medicaland Pharmaceutical Research.




Whole genome sequencing – determining the full sequence of DNA in an organism – has taught scientists a huge amount about biology. However, what is often lacking is a picture of how those pieces of DNA are arranged. Hi-Co – a new technology for analysing nucleosome positions and orientations across the genome – could change this, by bringing together next-generation sequencing experiments and super-computer simulations.

Researcher Profile

Taniguchi group at iCeMS in Kyoto University: Biological functions such as cellular  differentiation are often regulated by vast numbers of molecules. Elucidating the general
principles behind the organization of these complex molecular environments is a critical challenge. Our laboratory addresses this challenge by developing new technologies for the large scale characterization and manipulation of intracellular molecular activities. By integrating knowledge from multiple academic fields, including biology, chemistry, physics, medicine, and
informatics, we aim to understand, predict, and control intracellular molecular interactions.

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